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Proguanil hydrochloride
CAS No. 637-32-1
Proguanil hydrochloride ( Proguanil Hydrochloride; Paludrine; Chloroguanide hydrochloride )
Catalog No. M18939 CAS No. 637-32-1
Proguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 45 | In Stock |
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| 10MG | 54 | In Stock |
|
| 25MG | 92 | In Stock |
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| 50MG | 171 | In Stock |
|
| 100MG | 306 | In Stock |
|
| 200MG | 491 | In Stock |
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| 500MG | 790 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameProguanil hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionProguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
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DescriptionProguanil Hydrochloride is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
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SynonymsProguanil Hydrochloride; Paludrine; Chloroguanide hydrochloride
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PathwayAutophagy
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TargetAutophagy
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Recptordihydrofolate reductase;thymidylate synthase;NADH dehydrogenase
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Research Area——
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Indication——
Chemical Information
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CAS Number637-32-1
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Formula Weight290.19
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Molecular FormulaC11H17Cl2N5
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Purity98%
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Solubility——
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SMILESCl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1
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Chemical Name(1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gerlinde F. Plger, etal. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Proguanil Hydrochloride[J]. Journal of Pharmaceutical Sciences, 2018, 163(4):1-21.
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